door bw | sep 10, 2013 | diabetes, wetenschap
Diabetes is associated with a high incidence of macrovascular disease (MVD), including peripheral and coronary artery disease. Circulating soluble-Klotho (sKlotho) is produced in the kidney and is a putative anti-aging and vasculoprotective hormone. Reduced Klotho levels may therefore increase cardiovascular risk in diabetes. We investigated if sKlotho levels are decreased in type 2 diabetes and associate with MVD in the absence of diabetic nephropathy, and whether hyperglycemia affects renal Klotho production in vitro and in vivo.
The full paper was published in Cardiovascular Diabetology (impact factor 4.21) by: van Ark J, Hammes HP, van Dijk MC, Lexis CP, van der Horst IC, Zeebregts CJ, Vervloet MG, Wolffenbuttel BHR, van Goor H, Hillebrands JL. , and can be read at: http://www.cardiab.com/content/12/1/116
door bw | sep 9, 2013 | wetenschap
Jeffrey Beall maintains a website which critically follows several open access publishers in the field of science. He even maintains a list of the publishers, which he calls “Potential, possible, or probable predatory publishers” (http://scholarlyoa.com/publishers/ and http://scholarlyoa.com/2012/12/06/bealls-list-of-predatory-publishers-2013/#more-1036 ). (meer…)
door bw | jun 25, 2013 | gezondheidszorg, wetenschap
Mitochondriale aandoeningen vormen een heterogene groep ziekten. In de mitochondriën wordt energie gefabriceerd door de verbranding van brandstoffen als pyruvaat (afkomstig van glucose) en vetzuren. Als gevolg van een onvoldoende functionerende mitochondriale ademhalingsketen, wordt er te weinig energie in de vorm van adenosinetrifosfaat (ATP) gesynthetiseerd. Dit leidt er toe dat organen met een hoge energiebehoefte, zoals het centrale zenuwstelsel, maar ook skeletspieren en de hartspier, niet goed kunnen functioneren. Wanneer door een mitochondriale stoornis pyruvaat niet aëroob kan worden afgebroken, vindt buiten de mitochondriën anaërobe afbraak tot lactaat plaats, hetgeen dan in abnormale concentraties in bloed en urine kan worden aangetoond.
(meer…)
door bw | jun 24, 2013 | schildklier, wetenschap
This article recently was published online in the journal Thyroid.
Klaver EI, van Loon HC, Stienstra R, Links TP, Keers JC, Kema IP, Muller Kobold AC, Van der Klauw MM, Wolffenbuttel BHR.
Source
University of Groningen, University Medical Center Groningen, Endocrinology, Groningen, Netherlands
Part of the abstract
Methods: Cross-sectional study of Dutch adults participating in the LifeLines Cohort Study between December 2009 and August 2010. In 9491 Western European participants (median age 45 years; 3993 men and 5498 women), without current or former use of thyroid medication, we compared health-related quality of life (HR-QOL) using the RAND 36-Item Health Survey (RAND-36) between subjects with normal TSH values and subjects with disturbed thyroid hormone status (serum TSH, free T4 and free T3). The influence of possible confounders (age, smoking, co-morbidity) on HR-QOL was evaluated as well.
Results: Suppressed TSH values (TSH 10 mU/L. Men had a higher HR-QOL than women (70 – 92 vs. 65 – 89; p<0.001), except for the domain ‘general health’ (72 vs. 72; p=0.692). Men with suppressed or elevated TSH values did not score significantly lower than euthyroid men for any of nine domains of the RAND-36. Compared with euthyroid women, women with suppressed TSH scored significantly lower in the domains ‘physical functioning’ (84 vs. 89, p=0.013) and ‘general health’ (67 vs. 72, p=0.036). Women with markedly elevated TSH (>10 mU/L) had a score in all HR-QOL domains that was similar to that of women with normal TSH. There were no differences in the Physical Composite Score and the Mental Composite Score between any of the TSH groups. PCS and MCS were mainly determined by smoking status, co-morbidity and BMI or waist circumference.
The full paper can be found at:
http://online.liebertpub.com/doi/abs/10.1089/thy.2013.0017
door bw | jun 24, 2013 | wetenschap
Boomsma DI, Wijmenga C, Slagboom EP, Swertz MA, Karssen LC, Abdellaoui A, Ye K, Guryev V, Vermaat M, van Dijk F, Francioli LC, Jan Hottenga J, Laros JF, Li Q, Li Y, Cao H, Chen R, Du Y, Li N, Cao S, van Setten J, Menelaou A, Pulit SL, Hehir-Kwa JY, Beekman M, Elbers CC, Byelas H, de Craen AJ, Deelen P, Dijkstra M, T den Dunnen J, de Knijff P, Houwing-Duistermaat J, Koval V, Estrada K, Hofman A, Kanterakis A, Enckevort DV, Mai H, Kattenberg M, van Leeuwen EM, Neerincx PB, Oostra B, Rivadeneira F, Suchiman EH, Uitterlinden AG, Willemsen G, Wolffenbuttel BHR, Wang J, de Bakker PI, van Ommen GJ, van Duijn CM.
Source
Department of Biological Psychology, VU University Amsterdam, Netherlands Twin Register, Amsterdam, The Netherlands, & many others.
Part of the abstract
Within the Netherlands a national network of biobanks has been established (Biobanking and Biomolecular Research Infrastructure-Netherlands (BBMRI-NL)) as a national node of the European BBMRI. One of the aims of BBMRI-NL is to enrich biobanks with different types of molecular and phenotype data. Here, we describe the Genome of the Netherlands (GoNL), one of the projects within BBMRI-NL. GoNL is a whole-genome-sequencing project in a representative sample consisting of 250 trio-families from all provinces in the Netherlands, which aims to characterize DNA sequence variation in the Dutch population. …………… The present paper summarizes the global characteristics of the project.
The whole article can be found at the website of the European Journal of Human Genetics, as an advance online publication, 29 May 2013; doi:10.1038/ejhg.2013.118.
http://www.nature.com/ejhg/journal/vaop/ncurrent/full/ejhg2013118a.html
door bw | jun 16, 2013 | ICT, wetenschap
Onderzoekers worden aangemoedigd om met speciale applicaties als ORCID of ResearcherID (van Thomsen Reuters) te werken. Ik heb ResearcherID al aantal maanden gebruikt, ziet er doortimmerd. uit, is gemakkelijk in het gebruik, en d eoverzichten zijn fraai.
Echter, recent gaan aantal uitgevers met ORCID in zee, je reviewer account wordt gekoppeld aan ORCID. Hindawi is één van de uitgevers die gedaan heeft. Ik weet niet waarom dat is, zo’n geweldige verbetering geeft dit ook niet. Het is namelijk tragisch dat ORCID zulke buggy software biedt. Vanmiddag zat ik mijn publicatie lijst op ORCID bij te werken, en ineens was de lijst leeg. Van 164 publicaties naar 0 in een seconde. Met het updaten gaat het ook niet geweldig. Artikelen sorteren is er nauwelijks bij. Op ieder bestaand artikel moet je klikken om ‘m van privé naar publiek om te zetten. De artikelen worden op volgorde van jaartal, en vervolgens alfabetisch weergegeven, op volgorde van de eerste letter van de titel van iedere publicatie. Als je in je account setting hebt aangegeven dat nieuwe publicaties direct ‘publiek’ getoond mogen worden, staat dit bij hernieuwd inloggen weer op ‘privé’. Het programma is te stom om zelf dubbele entries van de zelfde publicatie te herkennen, die moet je met de hand opsporen en wissen.
‘ORCID reageert niet’ is de meest voorkomende melding.
O ja, heb ik al vermeld hoe LAAAAAAAAAAANGZAAAAAM deze website is. Wat een crap.
Researchers are encouraged to have a unique ID. Systems for this are ORCID and ResearcherID (from Thomsen Reuters). I have used ResearcherID for several months, it is easy to use and gives a great overview.
Recently, some journal publishers started to use ORCID, one of them is Hindawi. Your reviewer account is connected to your ORCID account. I am not sure why. This is not a major step forward. It is tragic that ORCID offers such buggy software. This afternoon, while updating my piblication list, I lost all 164 publications in one second. Updating is a painful undertaking. Sorting articles is rather difficult, the only option is that they are sorted by publication year (descending), and than by title. Changing publications from private to public means thta you have to click on the ‘public’ sign for each and every article. If in your account setting you flag that new articles are set to public when you add them, when logging in again it shows that this is set to private again. The program is too stupid to recognize double entries, even if they are EXACTLY the same.
‘ORCID does not respond’ is the most frequently occurring error while workinhg in the system.
By the way, did I mention that the website is really SLOOOOOOOW? This is crap.
Recente reacties