John Mulder, CEO of Diagnoptics: “Mid September, a Dutch national newspaper devoted a full-page article to biological age and AGEs. It’s striking to see how a topic that once lived only in research papers and specialist discussions is now reaching a much wider audience.

Public awareness of biological age is clearly growing, not only among scientists and clinicians, but also within society at large. This raises an important question for all of us in the medical field: how do we translate this momentum into clinical practice?

AGEs remain underexplored in everyday healthcare. Yet early findings already suggest they can add value in prevention, patient engagement, and even perioperative decision-making. For me, this underscores the importance of bridging science and practice, ensuring that what we measure can truly drive better care.

Bron: LinkedIn

Please find below a list of our papers on Advanced Glycation Endproducts and skin autofluorescence.

1: Boersma HE, Sidorenkov G, Smit AJ, Paterson AD, van der Vegt B, Wolffenbuttel
BHR, van der Klauw MM, de Bock GH. Increased skin autofluorescence predicts
future cancer development. BMC Cancer. 2025 Aug 26;25(1):1375. doi:
10.1186/s12885-025-14801-w. PMID: 40859200; PMCID: PMC12379543.

2: Boersma HE, Smit AJ, Paterson AD, Wolffenbuttel BHR, van der Klauw MM. Skin
autofluorescence and cause-specific mortality in a population-based cohort. Sci
Rep. 2024 Aug 28;14(1):19967. doi: 10.1038/s41598-024-71037-7. PMID: 39198601;
PMCID: PMC11358541.

3: Boersma HE, Xia C, van der Klauw MM, Vonder M, Oudkerk M, van der Harst P,
Jan Pelgrim G, Wolffenbuttel BHR, Smit AJ, Vliegenthart R. Association between
skin autofluorescence and coronary calcification in the general population. PLoS
One. 2024 Aug 26;19(8):e0309059. doi: 10.1371/journal.pone.0309059. PMID:
39186712; PMCID: PMC11346912.

4: Vollenbrock CE, Roshandel D, van der Klauw MM, Wolffenbuttel BHR, Paterson
AD. Genome-wide association study identifies novel loci associated with skin
autofluorescence in individuals without diabetes. BMC Genomics. 2022 Dec
19;23(1):840. doi: 10.1186/s12864-022-09062-x. PMID: 36536295; PMCID:
PMC9764523.

5: Boersma HE, van der Klauw MM, Smit AJ, Wolffenbuttel BHR. A non-invasive risk
score including skin autofluorescence predicts diabetes risk in the general
population. Sci Rep. 2022 Dec 16;12(1):21794. doi: 10.1038/s41598-022-26313-9.
PMID: 36526712; PMCID: PMC9758123.

6: Boersma HE, van Waateringe RP, van der Klauw MM, Graaff R, Paterson AD, Smit
AJ, Wolffenbuttel BHR. Skin autofluorescence predicts new cardiovascular disease
and mortality in people with type 2 diabetes. BMC Endocr Disord. 2021 Jan
12;21(1):14. doi: 10.1186/s12902-020-00676-4. PMID: 33435948; PMCID: PMC7802158.

7: Wouters HJCM, van der Klauw MM, Wolffenbuttel BHR, Huls G, van Zeventer IA.
The Association Between Anemia and Skin Autofluorescence, a Marker for Advanced
Glycation End Product Accumulation. Hemasphere. 2020 Oct 26;4(6):e470. doi:
10.1097/HS9.0000000000000470. PMID: 33134864; PMCID: PMC7593064.

8: van Waateringe RP, Fokkens BT, Slagter SN, van der Klauw MM, van Vliet-
Ostaptchouk JV, Graaff R, Paterson AD, Smit AJ, Lutgers HL, Wolffenbuttel BHR.
Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease
and mortality in the general population. Diabetologia. 2019 Feb;62(2):269-280.
doi: 10.1007/s00125-018-4769-x. Epub 2018 Nov 21. PMID: 30460578; PMCID:
PMC6323092.

9: Van Waateringe RP, Truyens L, Van Den Berg PP, Lutgers HL, Wolffenbuttel BHR.
Skin autofluorescence, a non-invasive biomarker for advanced glycation end
products, is not related to the number of pregnancies. J Diabetes. 2018
Nov;10(11):899-901. doi: 10.1111/1753-0407.12782. Epub 2018 Jun 27. PMID:
29774665.

10: Fokkens BT, van Waateringe RP, Mulder DJ, Wolffenbuttel BHR, Smit AJ. Skin
autofluorescence improves the Finnish Diabetes Risk Score in the detection of
diabetes in a large population-based cohort: The LifeLines Cohort Study.
Diabetes Metab. 2018 Nov;44(5):424-430. doi: 10.1016/j.diabet.2017.09.002. Epub
2017 Oct 31. PMID: 29097003.

11: van Waateringe RP, Mook-Kanamori MJ, Slagter SN, van der Klauw MM, van
Vliet-Ostaptchouk JV, Graaff R, Lutgers HL, Suhre K, El-Din Selim MM, Mook-
Kanamori DO, Wolffenbuttel BHR. The association between various smoking
behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced
glycation end product accumulation. PLoS One. 2017 Jun 20;12(6):e0179330. doi:
10.1371/journal.pone.0179330. PMID: 28632785; PMCID: PMC5478117.

12: van Waateringe RP, Slagter SN, van Beek AP, van der Klauw MM, van Vliet-
Ostaptchouk JV, Graaff R, Paterson AD, Lutgers HL, Wolffenbuttel BHR. Skin
autofluorescence, a non-invasive biomarker for advanced glycation end products,
is associated with the metabolic syndrome and its individual components.
Diabetol Metab Syndr. 2017 May 30;9:42. doi: 10.1186/s13098-017-0241-1. PMID:
28572855; PMCID: PMC5450154.

13: Vollenbrock CE, Van Waateringe RP, Veeze HJ, Aanstoot HJ, Wolffenbuttel BH.
Skin autofluorescence is increased in young people with type 1 diabetes exposed
to secondhand smoking. J Diabetes. 2017 Mar;9(3):308-310. English. doi:
10.1111/1753-0407.12498. Epub 2016 Dec 1. PMID: 27787940.

14: Schutte E, de Vos LC, Lutgers HL, Lambers Heerspink HJ, Wolffenbuttel BH,
Vart P, Zeebregts CJ, Gansevoort RT, Lefrandt JD. Association of Skin
Autofluorescence Levels With Kidney Function Decline in Patients With Peripheral
Artery Disease. Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1709-14. doi:
10.1161/ATVBAHA.116.307771. Epub 2016 Jun 30. PMID: 27365407.

15: Roshandel D, Klein R, Klein BE, Wolffenbuttel BH, van der Klauw MM, van
Vliet-Ostaptchouk JV, Atzmon G, Ben-Avraham D, Crandall JP, Barzilai N, Bull SB,
Canty AJ, Hosseini SM, Hiraki LT, Maynard J, Sell DR, Monnier VM, Cleary PA,
Braffett BH; DCCT/EDIC Research Group; Paterson AD. New Locus for Skin Intrinsic
Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated
Proteins. Diabetes. 2016 Jul;65(7):2060-71. doi: 10.2337/db15-1484. Epub 2016
Apr 12. PMID: 27207532; PMCID: PMC4915582.

16: van Waateringe RP, Slagter SN, van der Klauw MM, van Vliet-Ostaptchouk JV,
Graaff R, Paterson AD, Lutgers HL, Wolffenbuttel BH. Lifestyle and clinical
determinants of skin autofluorescence in a population-based cohort study. Eur J
Clin Invest. 2016 May;46(5):481-90. doi: 10.1111/eci.12627. Epub 2016 Apr 15.
PMID: 27002914; PMCID: PMC5111733.

17: Eny KM, Lutgers HL, Maynard J, Klein BE, Lee KE, Atzmon G, Monnier VM, van
Vliet-Ostaptchouk JV, Graaff R, van der Harst P, Snieder H, van der Klauw MM,
Sell DR, Hosseini SM, Cleary PA, Braffett BH, Orchard TJ, Lyons TJ, Howard K,
Klein R, Crandall JP, Barzilai N, Milman S, Ben-Avraham D; LifeLines Cohort
Study Group; DCCT/EDIC Research Group; Wolffenbuttel BH, Paterson AD. GWAS
identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a
major locus for skin fluorescence. Diabetologia. 2014 Aug;57(8):1623-34. doi:
10.1007/s00125-014-3286-9. Epub 2014 Jun 17. PMID: 24934506; PMCID: PMC4079945.

18: Hartog JW, de Vries AP, Bakker SJ, Graaff R, van Son WJ, van der Heide JJ,
Gans RO, Wolffenbuttel BH, de Jong PE, Smit AJ. Risk factors for chronic
transplant dysfunction and cardiovascular disease are related to accumulation of
advanced glycation end-products in renal transplant recipients. Nephrol Dial
Transplant. 2006 Aug;21(8):2263-9. doi: 10.1093/ndt/gfl132. Epub 2006 Apr 5.
PMID: 16597636.

19: Mentink CJ, Hendriks M, Levels AA, Wolffenbuttel BH. Glucose-mediated cross-
linking of collagen in rat tendon and skin. Clin Chim Acta. 2002
Jul;321(1-2):69-76. doi: 10.1016/s0009-8981(02)00097-9. PMID: 12031595.

20: Huijberts MS, Wolffenbuttel BH, Crijns FR, Nieuwenhuijzen Kruseman AC,
Bemelmans MH, Struijker Boudier HA. Aminoguanidine reduces regional albumin
clearance but not urinary albumin excretion in streptozotocin-diabetic rats.
Diabetologia. 1994 Jan;37(1):10-4. doi: 10.1007/BF00428771. PMID: 8150221.

21: Huijberts M, Wolffenbuttel B, Crijns F, Kruseman AN, Bemelmans M, Van Essen
H, Smits J, Boudier HS. Inhibition of angiotensin-converting enzyme reduces
urinary albumin excretion but not regional albumin clearance in experimental
diabetes. Eur J Pharmacol. 1993 Aug 24;240(2-3):207-12. doi:
10.1016/0014-2999(93)90900-3. PMID: 8243539.