This article recently was published online in the journal Thyroid.
Klaver EI, van Loon HC, Stienstra R, Links TP, Keers JC, Kema IP, Muller Kobold AC, Van der Klauw MM, Wolffenbuttel BHR.
Source
University of Groningen, University Medical Center Groningen, Endocrinology, Groningen, Netherlands
Part of the abstract
Methods: Cross-sectional study of Dutch adults participating in the LifeLines Cohort Study between December 2009 and August 2010. In 9491 Western European participants (median age 45 years; 3993 men and 5498 women), without current or former use of thyroid medication, we compared health-related quality of life (HR-QOL) using the RAND 36-Item Health Survey (RAND-36) between subjects with normal TSH values and subjects with disturbed thyroid hormone status (serum TSH, free T4 and free T3). The influence of possible confounders (age, smoking, co-morbidity) on HR-QOL was evaluated as well.
Results: Suppressed TSH values (TSH 10 mU/L. Men had a higher HR-QOL than women (70 – 92 vs. 65 – 89; p<0.001), except for the domain ‘general health’ (72 vs. 72; p=0.692). Men with suppressed or elevated TSH values did not score significantly lower than euthyroid men for any of nine domains of the RAND-36. Compared with euthyroid women, women with suppressed TSH scored significantly lower in the domains ‘physical functioning’ (84 vs. 89, p=0.013) and ‘general health’ (67 vs. 72, p=0.036). Women with markedly elevated TSH (>10 mU/L) had a score in all HR-QOL domains that was similar to that of women with normal TSH. There were no differences in the Physical Composite Score and the Mental Composite Score between any of the TSH groups. PCS and MCS were mainly determined by smoking status, co-morbidity and BMI or waist circumference.
The full paper can be found at:
http://online.liebertpub.com/doi/abs/10.1089/thy.2013.0017
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