Een nieuw artikel is zojuist gepubliceerd, als resultaat van onze vruchtbare samenwerking met de groep van Andrew Paterson, verbonden aan het “Hospital for Sick Children” in Toronto, Canada, en vele andere onderzoekers.
Titel: A New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes also Associated with Blood and Skin Glycated Proteins.
Authors: Roshandel D, Klein R, Klein BE, Wolffenbuttel BHR, van der Klauw MM, van Vliet-Ostaptchouk JV, Atzmon G, Ben-Avraham D, Crandall JP, Barzilai N, Bull SB, Canty AJ, Hosseini SM, Hiraki LT, Maynard J, Sell DR, Monnier VM, Cleary PA, Braffett BH; DCCT/EDIC Research Group, Paterson AD.
Journal: Diabetes. 2016 Apr 12. pii: db151484. [Epub ahead of print]
Abstract
Skin fluorescence (SF) non-invasively measures advanced glycation end products (AGEs) in the skin and is a risk indicator for diabetic complications. N-acetyltransferase 2 (NAT2) is the only known locus influencing SF. We aimed to identify additional genetic loci influencing SF in type 1 diabetes (T1D) through a meta-analysis of genome-wide association studies (GWAS) (N = 1,359) including the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) and Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) studies. A locus on chromosome 1, rs7533564 (p = 1.9×10-9), was associated with skin intrinsic fluorescence (SIF) measured by SCOUT DS (excitation: 375nm, emission: 435-655nm) which remained significant after adjustment for time-weighted HbA1c (p = 1.7×10-8). rs7533564 was associated with mean HbA1c in meta-analysis (p = 0.0225), mean glycated albumin (p = 0.0029) and glyoxal hydroimidazolones (p = 0.049), an AGE measured in skin biopsy collagen, in DCCT. rs7533564 was not associated with diabetic complications in DCCT/EDIC, nor with SF in non-diabetic (ND) subjects (N = 8,721). In conclusion, we identified a new locus associated with SF in T1D subjects which did not show similar effect in ND subjects suggesting diabetes-specific effect. This association needs to be investigated in type 2 diabetes.
Find the full paper here: http://diabetes.diabetesjournals.org/content/early/2016/04/07/db15-1484.long
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